Dr. Ilfir R. Ramazanov

 

Laboratory of Catalytic Synthesis, Institute of Petrochemistry and Catalysis,

pr. Oktyabrya 141, Ufa, 450075, Russia

E-mail: chemelf@hotbox.ru, Tel.: +7 (3472) 313527 (work), Fax.: +7 (3472) 312750

 

EDUCATION

 

1994­-1998	Ph.D. in Organic Chemistry Prof. U.M. Dzhemilev, Institute of Petrochemistry and Catalysis of Ufa Research Centre of the Russian Academy of Sciences, Ufa, Russia.   "Hydro- and Cycloalumination of Disubstituted Alkynes by Trialkyl- and Alkylhaloaluminium in the Presence of Metallocomplex Catalysts"
1989­-1994	M.S. in Chemistry Prof. R.F. Talipov, Chemistry Department, Bashkir State University, Ufa, Russia.   "Investigation of Prins Reaction with Allyl Esters in Sulphuric Acid Media"

RESEARCH EXPERIENCE

 

2005/09-present	Senior Research Scientist Prof. U.M. Dzhemilev, Institute of Petrochemistry and Catalysis of Russian Academy of Sciences, Ufa, Russia. Organometallic chemistry: Carbolithiation of alkenes and alkynes.
2003/02-2004/08	Research Scholar Prof. Ei-ichi Negishi , Chemistry Department, Purdue University, West Lafayette, Indiana, USA.   Organometallic chemistry: Enantioselective carboalumination. (NMI)2ZrCl2 catalyzed enantioselective carboalumination of a,w-dienes and haloalkenes was studied.
2001/10-2002/09	Post Doctoral fellowship of The Council for Higher Education in Israel Prof. J.T. Klug, Institutes for Applied Research, Ben-Gurion University of the Negev, Beer-Sheva, Israel.   Organic synthesis: Fluorescent markers for biological systems. Synthesized new fluorescent markers for protein structure studying based on pyrene and naphthalene derivatives.
2000/03-2001/09	Senior Research Scientist Prof. U.M. Dzhemilev, Institute of Petrochemistry and Catalysis of Ufa Research Centre of the Russian Academy of Sciences, Ufa, Russia. Organometallic chemistry: Cyclic carboalumination of alkynes; Reactions of cyclic organoaluminium compounds; Cyclopropanation of alkynes; Radical hydroalkylation of alkenes. Developed reactions of 2,3-disubstituted aluminacyclopent-2-enes to prepare 1,1-disubstituted cyclopropanes; Alkyne cyclopropanation by CH2I2-Et3Al reagent was realized; Cp2TiCl2 catalyzed hydroalkylation of alkenes by t-BuBr.
1998/12-2000/03	Research Scientist Prof. U.M. Dzhemilev, Institute of Petrochemistry and Catalysis of Ufa Research Centre of the Russian Academy of Sciences, Ufa, Russia. Organometallic chemistry: Cycloalumination of alkynes; First synthesis of aluminacyclopropenes and new approach to preparation of aluminacyclopentadienes.

 

RESEARCH INTERESTS

 

Focused toward to the following:

 

(i) Development of new synthetic procedures based on application of organometallic reagents and/or metallocomplex catalysts.  Currently it includes reactions of  organometallic compounds of Al, Mg and Li with substrates containing double and triple carbon-carbon bond catalyzed by Zr, Ti, Pd and Ni complexes.

 

(ii) Enantioselective addition to double carbon-carbon bond induced by chiral complexes of transition metals. Computational modelling of chiral transitions states for preliminary screening of enantioselective catalysts.

 

 

SELECTED SKILLS

 

Experimental methods:

-        Synthesis and handling of air- and moistsensitive compounds

-         Chemistry of organoaluminium, -lithium, -magnesium and -sodium compounds (preparation and reactions)

-        Chemistry of Ti-, Zr-, Ni- and Pd complexes with chiral ligands

-        Chemistry of pyrene and naphthalene

 

Instrumental techniques:

-         Separation (analytical and preparative GC-FID/TCD, TLC, HPLC, flash chromatography)

-         Structural analysis (FT-NMR (Varian Gemini-200, Varian Mercury-300), FT-IR, enantiomeric excess estimation by Mosher method (MTPA esters))

-         Reaction mechanism (low-temperature FT-NMR)

 

Computational techniques:

-         Correlated Hartree-Fock and DFT calculations

-         Calculations of reaction energies and reaction barriers

 

Computer skills:

-         SciFinder, Belstein Crossfire, ChemOffice, ISIS Draw, HP Chemstation, ACDLab

-         Gaussian, Gamess, Mopac, Spartan, Titan, Tinker, Hyperchem

-         Word, Excel, Access, EndNote, SigmaPlot, Origin

-         Delphi, Fortran, Pascal, C, Basic, Assembly language, HTML

-         Windows, MS-DOS, Sun OS

 

Language:

-        Russian (native language)

-         English (fluently speaking, reading and writing)

-         German (reading and writing)

-        French (basic knowledge)

 

Organizing and writing:

-         Supervising over the group of three PhD students (planning, writing)

 

 

SCHOLARSHIPS AND AWARDS

 

2001-2002	Post Doctoral fellowship of The Council for Higher Education in Israel Institutes for Applied Research, Ben-Gurion University of the Negev, Beer-Sheva, Israel
1997	Scholarship of the International Soros Science Educational Program (Soros postgraduate student) Institute of Petrochemistry and Catalysis of Ufa Research Centre of the Russian Academy of Sciences
1996	Scholarship of Bashkortostan Republic Government Institute of Petrochemistry and Catalysis of Ufa Research Centre of the Russian Academy of Sciences

 

GRANTS

 

-         Russian Foundation of Basic Research (RFBR) Grant "New approaches to cyclopropane synthesis " (2001-2003)

-         INTAS grant "Double asymmetric induction in reactions with chiral complexes of transition metals" (2000-2001)

-        Russian Foundation of Basic Research (RFBR) Grant "Leading russian scientific schools" (2000-2002)

-         Russian Foundation of Basic Research (RFBR) Grant "Synthesis and selective functionalization of carbon- and metal-containing cluster compounds" (2000-2002)

-         Russian Foundation of Basic Research (RFBR) Grant " Development of new hydrometallation reagents for regio- and stereoselective reduction of alkenes and alkynes" (1998-2000)

-         Russian Foundation of Basic Research (RFBR) Grant "Development of methods of metallacyclopropane synthesis based on Mg and Al compounds in the presence of metallocomplex catalysts" (1997-1999)

-         Fund of support of scientific schools "Metallocomplex catalysis in organic and organometallic synthesis" sponsored by the Russian Foundation of Basic Researches (1996-1997)

 

 

PROFESSIONAL ASSOCIATIONS

 

2002	Member of the Israel Chemical Society

 

JOURNAL PUBLICATIONS

 

-         U. M. Dzhemilev, I. R. Ramazanov. "Ethylaluminium dichloride" //EROS. (prepared for publication)

-         I. R. Ramazanov, A. Z. Sharipova, U. M. Dzhemilev. "¹³C NMR study of terminal alkyne hydroalumination"· (prepared for publication)

-         I. R. Ramazanov, A. Z. Sharipova, U. M. Dzhemilev. "Cp₂TiCl₂-catalyzed hydroalkylation of cycloalkenes with Bu^tBr-Et₃Al" //Russ. J. Org. Chem.. (submitted for publication)

-         I. R. Ramazanov, T. Novak, E.-i. Negishi. "Zr-catalyzed enantioselective carboalumination of a,w-dienes" // J. Am. Chem. Soc. (submitted for publication).

-         I. R. Ramazanov, L. I. Djyatchenko, A. G. Ibragimov, U. M. Dzhemilev. "Cp₂TiCl₂-catalyzed hydroalkylation of alpha-olefins with Bu^tBr-Et₃Al"· //Russ. Chem. Bull., 51 (5), P.833-835, MAY 2002

-         U. M. Dzhemilev, A. G. Ibragimov, L. O. Khafizova, I. R. Ramazanov, D. F. Yalalova, G. A. Tolstikov."One-pot synthesis of 1,1-disubstituted cyclopropanes in the presence of metal complex catalysts" //J. Organomet. Chem., 636 (1-2), P.76-81, Sp. Iss. SI NOV 25 2001

-         U. M. Dzhemilev, I. R. Ramazanov, A. G. Ibragimov, M. P. Lukjyanova, L. I. Djyatchenko, O. M. Nefedov. "Acetylene cyclopropanation by CH₂I₂-Et₃Al Reagent" //J. Organomet. Chem., 636 (1-2), P.91-95, Sp. Iss. SI NOV 25 2001

-         I. R. Ramazanov, M. P. Lukjyanova, A. Z. Sharipova, A. G. Ibragimov, U. M. Dzhemilev, O. M. Nefedov. "One-step cyclopropanation of alkynes by CH₂I₂ and Et₃Al" //Russ. Chem. Bull., 50:(8), P.1406-1409, AUG 2001

-         U. M. Dzhemilev, A. G. Ibragimov, I. R. Ramazanov, M. P. Lukjyanova, A. Z. Sharipova. "Zr-catalyzed cycloalumination of asymmetric disubstituted acetylenes" //Russ. Chem. Bull., 50:(3), P.484-487, MAR 2001

-         U. M. Dzhemilev, A. G. Ibragimov, I. R. Ramazanov, M. P. Lukjyanova, A. Z. Sharipova, L. M. Khalilov. "A novel method to synthesize 1,1-alkylcyclopropanes" //Russ. Chem. Bull, 49:(6), P. 1086-1089, JUN 2000

-         A. G. Ibragimov, I. R. Ramazanov, L. M. Khalilov, U. M. Dzhemilev. "Aluminacyclopropenes, a novel series of organoaluminum compounds" // Russ. Chem. Bull., 46: (12), P. 2150-2152, DEC 1997.

-         R. R. Muslukhov, L. M. Khalilov, I. R. Ramazanov, A. Z. Sharipova, A. G. Ibragimov, U. M. Dzhemilev. "NMR ¹³C spectra and electronic structure of alkenylalanes" //Russ. Chem. Bull., 46: (12), P. 2082-2085, DEC 1997.

-         A. G. Ibragimov, I. R. Ramazanov, L. M. Khalilov, R. M. Sultanov, U. M. Dzhemilev. "Regio- and stereoselective hydroalumination of disubstituted acetylenes with Et₃Al catalysed by Cp₂TiCl₂" //Mendeleev Commun., 6, P.231-232, NOV 1996.

-         U. M. Dzhemilev, A. G. Ibragimov, I. R. Ramazanov, R. M. Sultanov, L. M. Khalilov, R. R. Muslukhov. "Buⁱ₂AlCl-Cp₂TiCl₂ - A new reagent for hydroalumination of disubstituted acetylenes" //Russ. Chem. Bull., 45: (11), P. 2610-2613, NOV 1996.

 

 

RECENT PRESENTATIONS

 

-         I.R. Ramazanov, E.-i. Negishi. "Zr-Catalyzed Enantioselective Carboalumination of a,w-dienes"//The 21^st Herbert C. Brown Lectures in Organic Chemistry, Organometallics in Organic Synthesis, April 3, 2004.

-         I.R. Ramazanov, J.T. Klug, V. Khodorkovsky "Theoretical study on electrophylic substitution in pyrene"//The 67^th meeting of the Israel chemical society, Jerusalem, Israel, January 29-30, 2002.

 

The total number of  journal publications and patents is 41.